|
KMID : 0378019780210050056
|
|
New Medical Journal
1978 Volume.21 No. 5 p.56 ~ p.64
|
|
|
Metabolic Effects in Massive Small Bowel Resection in Rats
|
|
|
|
|
Abstract
|
|
|
|
Occasionally a severe pathologic condition in the abdomen requires the resection of an extensive amount of the small intestine, for the surgeon is confronted at operation with the alternative of allowing the patient to die or restoring to a heroic effort to save the individual by resection. The problem arise in cases such as mesenteric thrombosis, volvulus and intussusception, extensive neoplastic disease or inflammatory conditions of the intestine. The problems associated with massive resection of the small intestine are multiple and serious such as intractable diarrhea, malabsorption, chronic vitamin deficiencies and weight loss. Therefore the present experimental study was performed in an attempt to evaluate the metabolic effects of some variants of the intestinal resection and observed changes of weight, serum cholesterol, liver function, serum electrolytes and hematologic findings. The experimental rats were divided into 3 groups; as group I (Sham operation, control), group II (distal 70% resection of small intestine), and group III (proximal 70% resection of small intestine). All experimental rats were checked the body weight every two day after operation. A half of animals of each group were sacrificed on 7th postoperative day and the remained animals on 21th postoperative day. Blood was collected for chemical analysis and hematologic studies; the liver and intestine was taken for histopathologic examination. The author compared the results of each groups and all data were analysed statistically. The results were as follows: 1. When comparing the parameters of postoperative weight gain, there was remarkable weight loss in resection groups; especially distal resection group was noted significant weight loss from proximal resection group. 2. The serum cholesterol level was considerably decreased in distal resection group (30.6±3.2 mg/100 ml) and proximal resection group (44.21?5.8mg/100 ml) ; than in control (68.4?5.8mg/l00ml) at 7th postoperative day; at 21th postoperative day, distal resection group (24.2?7.0mg/ 100 ml) , proximal resection group (48.6±4.4mg/100 ml) , control (68.3?5.7 mg/100 ml). 3. The liver function was within normal limits in proximal resection group but remarkable decrease of liver function was noted in distal resection group. 4. No statistical reduction of hemoglobin, hematocrit and serum electrolytes was noted between in each groups. 5. Histologic sections of the liver demonstrated slight fatty infiltration associated with inflammatory cell infiltration at periportal region in proximal resection group and generalized marked fatty infiltration in distal resection group. Sections of the intestine showed hypertrophy of the intestinal villi and increased mucosal thickness in each groups. These morphologic changes were progressed with time especially in the mucosa and submucosa layer of the intestine. With the above results, author conclude that the effects on metabolic basis in massive small bowel resection in rats were profound in distal resection group than in proximal resection group.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|